Page last updated: 2024-10-24

NatA complex

Definition

Target type: cellularcomponent

A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins. [PMID:12890471]

The NatA complex is a multi-protein complex responsible for the acetylation of the N-terminal methionine of newly synthesized proteins. This complex is found in the cytoplasm and is composed of two core subunits: N-terminal acetyltransferase A (NatA) and the auxiliary subunit NAA10. NatA is the catalytic subunit and is responsible for transferring the acetyl group from acetyl-CoA to the N-terminal methionine. NAA10 acts as a scaffold protein, promoting the interaction of NatA with its substrates and increasing its catalytic activity. The NatA complex is important for protein folding, stability, and function. It can also regulate protein interactions and cellular localization. Specifically, the cellular component of the NatA complex is the cytoplasm, where it interacts with newly synthesized proteins emerging from ribosomes. The NatA complex is localized in the cytoplasm, where it interacts with the ribosomes and the newly synthesized proteins. The complex has a high affinity for the ribosome, allowing it to quickly access and modify the N-terminal methionine of nascent proteins. This cytoplasmic localization ensures that the NatA complex can efficiently acetylate proteins as they are being synthesized.'
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Proteins (1)

ProteinDefinitionTaxonomy
N-alpha-acetyltransferase 50An N-alpha-acetyltransferase 50 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZZ1]Homo sapiens (human)

Compounds (2)

CompoundDefinitionClassesRoles
coenzyme aadenosine 3',5'-bisphosphatecoenzyme;
Escherichia coli metabolite;
mouse metabolite
acetyl coenzyme aAcetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.acyl-CoAacyl donor;
coenzyme;
effector;
fundamental metabolite