NURF complex
Definition
Target type: cellularcomponent
An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters. [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179]
The NURF (Nucleosome Remodeling Factor) complex is a multi-protein complex involved in chromatin remodeling and transcription regulation. Its cellular component is predominantly localized to the nucleus, where it interacts with nucleosomes and DNA. The NURF complex consists of two main subunits: \\n\\n1. **NURF301 (CHD3)**: This is the catalytic subunit responsible for ATP-dependent nucleosome sliding and repositioning. NURF301 possesses a chromodomain that binds to histone H3 tails with specific modifications, particularly H3K4 methylation. \\n2. **NURF55 (SNF2H)**: This subunit functions as a scaffold protein, connecting the NURF301 subunit to other components of the complex. It also contributes to DNA binding and interaction with other transcription factors. \\n\\nThe NURF complex also includes several other proteins, including: \\n\\n* **BPTF (Bromodomain PHD Finger Transcription Factor)**: This protein binds to acetylated histones and is involved in targeting the NURF complex to specific genomic regions. \\n* **RAP1 (Repressor Activator Protein 1)**: This protein interacts with NURF301 and is involved in gene activation. \\n* **MTA1 (Metastasis-Associated Protein 1)**: This protein is involved in chromatin remodeling and interacts with other transcription factors. \\n\\nThe NURF complex is a dynamic complex that can undergo various modifications, including phosphorylation, acetylation, and ubiquitination, which influence its activity and interactions with other proteins. \\n\\nOverall, the NURF complex plays a crucial role in regulating gene expression by influencing chromatin structure and facilitating transcription factor access to DNA. Its cellular localization within the nucleus allows it to directly interact with nucleosomes and other nuclear components involved in gene regulation.'
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Proteins (3)
| Protein | Definition | Taxonomy |
|---|---|---|
| Histone-binding protein RBBP7 | A histone-binding protein RBBP7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16576] | Homo sapiens (human) |
| Nucleosome-remodeling factor subunit BPTF | A nucleosome-remodeling factor subunit BPTF that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12830] | Homo sapiens (human) |
| Histone-binding protein RBBP4 | A histone-binding protein RBBP4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q09028] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| przewaquinone d | przewaquinone D: isolated from root of Salvia przewalskii; structure given in first source; RN given refers to the trans- isomer, przewaquinone D | ||
| bi 2536 | |||
| au-1 | |||
| i-bet726 | |||
| epz-6438 | tazemetostat: a histone methyltransferase EZH2 inhibitor with antineoplastic activity | ||
| gsk343 | GSK343 : A member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM). GSK343: an EZH2 methyltransferase inhibitor | aminopyridine; indazoles; N-alkylpiperazine; N-arylpiperazine; pyridone; secondary carboxamide | antineoplastic agent; apoptosis inducer; EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor |