1-alkyl-2-acetylglycerophosphocholine esterase complex

Definition

Target type: cellularcomponent

An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF). [GOC:jl, PMID:10542206]

The 1-alkyl-2-acetylglycerophosphocholine esterase complex is a multi-protein complex involved in the metabolism of ether lipids. This complex resides in the endoplasmic reticulum (ER), a cellular organelle responsible for protein synthesis, lipid metabolism, and calcium storage. Specifically, the complex localizes to the ER membrane, where it interacts with other enzymes and proteins involved in lipid biosynthesis and signaling. The ER membrane provides a platform for the complex to access its substrate, 1-alkyl-2-acetylglycerophosphocholine (platelet-activating factor or PAF), and facilitate its breakdown. The complex is composed of several proteins, including:

* **PAF acetylhydrolase (PAF-AH):** The primary catalytic component of the complex, responsible for hydrolyzing the acetyl group from PAF.
* **Lysophospholipase A1 (LPLA1):** This enzyme removes the fatty acid from the sn-1 position of lysophospholipids, including lysoPAF, a product of PAF-AH activity.
* **Other associated proteins:** The complex may include additional proteins that regulate its activity, facilitate its localization within the ER, or interact with other cellular pathways.

The precise organization and interactions of the proteins within the 1-alkyl-2-acetylglycerophosphocholine esterase complex are still being investigated. However, it is clear that this complex plays a critical role in regulating PAF levels, a potent lipid mediator involved in inflammation, platelet activation, and other cellular processes.'
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Proteins (1)

Compounds (1)