Swr1 complex

Definition

Target type: cellularcomponent

A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820]

The SWR1 complex is a chromatin remodeling complex that plays a crucial role in the deposition of the histone variant H2A.Z into nucleosomes. The complex is composed of multiple subunits, each contributing to its specific function. The core subunits include:

* **Swr1:** This ATPase subunit is the catalytic engine of the complex, utilizing the energy from ATP hydrolysis to move and reposition nucleosomes. It directly interacts with the nucleosome and facilitates the exchange of H2A for H2A.Z.
* **Yaf9:** This subunit functions as a scaffold, holding the other subunits together and contributing to the stability of the complex. It also interacts with the nucleosome, helping to position it for H2A.Z deposition.
* **Rvb1/2:** These two subunits, Rvb1 and Rvb2, are ATPases that act as chaperones for the complex. They assist in the proper assembly and disassembly of the SWR1 complex, ensuring its functional integrity.
* **Swc2/Swc5:** These two subunits, Swc2 and Swc5, act as histone chaperones. They bind to H2A.Z and deliver it to the nucleosome, facilitating the exchange with the canonical H2A histone.
* **Swc4/Swc6/Swc7:** These subunits, Swc4, Swc6, and Swc7, are involved in regulating the activity of the complex. They contribute to the targeting of the SWR1 complex to specific genomic regions and may also play a role in controlling the efficiency of H2A.Z deposition.

These subunits work together in a coordinated manner to ensure the accurate and efficient deposition of H2A.Z into nucleosomes. The SWR1 complex plays a vital role in various cellular processes, including gene regulation, DNA repair, and development. Its ability to replace canonical H2A with H2A.Z allows for the modulation of chromatin structure and gene expression, contributing to the dynamic regulation of cellular functions.'
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Proteins (3)

Compounds (8)