Swr1 complex
Definition
Target type: cellularcomponent
A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820]
The SWR1 complex is a chromatin remodeling complex that plays a crucial role in the deposition of the histone variant H2A.Z into nucleosomes. The complex is composed of multiple subunits, each contributing to its specific function. The core subunits include:
* **Swr1:** This ATPase subunit is the catalytic engine of the complex, utilizing the energy from ATP hydrolysis to move and reposition nucleosomes. It directly interacts with the nucleosome and facilitates the exchange of H2A for H2A.Z.
* **Yaf9:** This subunit functions as a scaffold, holding the other subunits together and contributing to the stability of the complex. It also interacts with the nucleosome, helping to position it for H2A.Z deposition.
* **Rvb1/2:** These two subunits, Rvb1 and Rvb2, are ATPases that act as chaperones for the complex. They assist in the proper assembly and disassembly of the SWR1 complex, ensuring its functional integrity.
* **Swc2/Swc5:** These two subunits, Swc2 and Swc5, act as histone chaperones. They bind to H2A.Z and deliver it to the nucleosome, facilitating the exchange with the canonical H2A histone.
* **Swc4/Swc6/Swc7:** These subunits, Swc4, Swc6, and Swc7, are involved in regulating the activity of the complex. They contribute to the targeting of the SWR1 complex to specific genomic regions and may also play a role in controlling the efficiency of H2A.Z deposition.
These subunits work together in a coordinated manner to ensure the accurate and efficient deposition of H2A.Z into nucleosomes. The SWR1 complex plays a vital role in various cellular processes, including gene regulation, DNA repair, and development. Its ability to replace canonical H2A with H2A.Z allows for the modulation of chromatin structure and gene expression, contributing to the dynamic regulation of cellular functions.'
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Proteins (3)
| Protein | Definition | Taxonomy |
|---|---|---|
| RuvB-like 1 | A RuvB-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y265] | Homo sapiens (human) |
| RuvB-like 2 | A RuvB-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y230] | Homo sapiens (human) |
| Histone acetyltransferase KAT5 | A histone acetyltransferase KAT5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92993] | Homo sapiens (human) |
Compounds (8)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| epigallocatechin gallate | (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis) | flavans; gallate ester; polyphenol | antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite |
| coenzyme a | adenosine 3',5'-bisphosphate | coenzyme; Escherichia coli metabolite; mouse metabolite | |
| anacardic acid | anacardic acid : A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities. anacardic acid: isolated from Anacardium occidentale; monophenol monooxygenase inhibitor | hydroxy monocarboxylic acid; hydroxybenzoic acid | anti-inflammatory agent; antibacterial agent; anticoronaviral agent; apoptosis inducer; EC 2.3.1.48 (histone acetyltransferase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; neuroprotective agent; plant metabolite |
| sorafenib | (trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; phenylureas; pyridinecarboxamide | angiogenesis inhibitor; anticoronaviral agent; antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; ferroptosis inducer; tyrosine kinase inhibitor | |
| rottlerin | rottlerin : A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis. rottlerin: an angiogenesis inhibitor; an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III; RN refers to (E)-isomer; do not confuse this chalcone with an anthraquinone that is also called rottlerin (RN 481-72-1); | aromatic ketone; benzenetriol; chromenol; enone; methyl ketone | anti-allergic agent; antihypertensive agent; antineoplastic agent; apoptosis inducer; K-ATP channel agonist; metabolite |
| 2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid | hydroxybenzoic acid | ||
| 1,2-bis(isothiazol-5-yl)disulfane | 1,2-bis(isothiazol-5-yl)disulfane: structure in first source | ||
| akt-i-1,2 compound | Akt-I-1,2 compound: an aminopeptidase P inhibitor; structure in first source |