vacuolar proton-transporting V-type ATPase, V1 domain
Definition
Target type: cellularcomponent
The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. [GOC:mah, PMID:16449553]
The V1 domain of the vacuolar proton-transporting V-type ATPase (V-ATPase) is a multi-subunit complex responsible for ATP hydrolysis. It is located on the cytosolic side of the vacuolar membrane and is connected to the V0 domain, which spans the membrane, through a central stalk. The V1 domain is composed of eight subunits: A, B, C, D, E, F, G, and H. These subunits are arranged in a ring-like structure, with the A and B subunits forming the catalytic core of the enzyme. The A subunit contains the ATP-binding site, while the B subunit is involved in the release of ADP and phosphate. The C subunit acts as a stator, preventing the rotation of the V1 domain during ATP hydrolysis. The D, E, F, G, and H subunits are peripheral subunits that contribute to the stability and proper functioning of the V1 domain. The rotation of the V1 domain, driven by ATP hydrolysis, is coupled to the proton translocation activity of the V0 domain, resulting in the pumping of protons into the vacuole. This process is crucial for maintaining the pH gradient across the vacuolar membrane, which is essential for various cellular processes such as nutrient uptake, protein sorting, and detoxification.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| V-type proton ATPase subunit B, brain isoform | A V-type proton ATPase subunit B, brain isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21281] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| enoxacin | enoxacin : A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 position. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea. Enoxacin: A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID. | 1,8-naphthyridine derivative; amino acid; fluoroquinolone antibiotic; monocarboxylic acid; N-arylpiperazine; quinolone antibiotic | antibacterial drug; DNA synthesis inhibitor |