Target type: biologicalprocess
The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A. [GOC:yaf]
The malonyl-CoA catabolic process involves the breakdown of malonyl-CoA, a key intermediate in fatty acid biosynthesis. It begins with the decarboxylation of malonyl-CoA, catalyzed by the enzyme malonyl-CoA decarboxylase. This reaction releases carbon dioxide and forms acetyl-CoA, a crucial substrate for various metabolic pathways. Malonyl-CoA decarboxylase is tightly regulated, ensuring that the flow of carbon through fatty acid biosynthesis is controlled. The malonyl-CoA catabolic process is essential for maintaining cellular energy balance and preventing the accumulation of malonyl-CoA, which can have detrimental effects on cell function.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Malonyl-CoA decarboxylase, mitochondrial | A malonyl-CoA decarboxylase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95822] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| methyl 5-(n-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)morpholine-4-carboxamido)pentanoate | methyl 5-(N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)morpholine-4-carboxamido)pentanoate: a malonyl-CoA decarboxylase inhibitor; structure in first source |