positive regulation of integrin-mediated signaling pathway
Definition
Target type: biologicalprocess
Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway. [GOC:obol]
Positive regulation of integrin-mediated signaling pathway is a complex and essential biological process that involves a series of molecular events triggered by the binding of extracellular matrix (ECM) components to integrin receptors on the cell surface. Integrins are transmembrane proteins that act as bridges between the ECM and the intracellular cytoskeleton, playing a critical role in cell adhesion, migration, proliferation, and differentiation.
Upon ECM binding, integrins undergo conformational changes that activate downstream signaling pathways. These pathways are highly interconnected and involve a cascade of protein-protein interactions, phosphorylation events, and the recruitment of adaptor proteins.
Key components of the integrin signaling pathway include:
* **Focal adhesion kinase (FAK):** A cytoplasmic tyrosine kinase that is activated upon integrin clustering. FAK phosphorylation triggers the recruitment of other signaling molecules, such as Src and PI3K, to the focal adhesion complex.
* **Src family kinases (SFKs):** These kinases are also activated by integrin engagement and phosphorylate various substrates, including FAK and other signaling proteins.
* **Phosphoinositide 3-kinase (PI3K):** This enzyme is activated by integrins and generates phosphatidylinositol 3,4,5-trisphosphate (PIP3), a lipid second messenger that regulates cell growth, survival, and migration.
* **Ras GTPase:** Activated by PI3K, Ras is a small GTPase that plays a central role in regulating cell proliferation and differentiation.
* **Mitogen-activated protein kinases (MAPKs):** Integrin signaling can activate various MAPKs, including ERK, JNK, and p38, which are involved in a wide range of cellular processes.
The activation of these signaling pathways leads to a diverse array of cellular responses, including:
* **Cell adhesion and spreading:** Integrin signaling promotes the formation of focal adhesions, which are specialized structures that link the ECM to the actin cytoskeleton. This allows cells to adhere to their surroundings and spread out.
* **Cell migration:** Integrin signaling regulates the assembly and disassembly of focal adhesions, allowing cells to migrate in response to external cues.
* **Cell proliferation and survival:** Integrin signaling can promote cell growth and survival by activating downstream pathways that regulate gene expression and protein synthesis.
* **Cell differentiation:** Integrin signaling can influence cell fate by regulating the expression of genes involved in specific cell types.
The positive regulation of integrin-mediated signaling pathway is essential for normal cellular function and development. Disruptions in this pathway can contribute to various diseases, including cancer, fibrosis, and inflammatory disorders.
In summary, the positive regulation of integrin-mediated signaling pathway involves a complex interplay of molecular events that are triggered by integrin engagement with the ECM. These events lead to the activation of downstream signaling pathways that control a wide range of cellular processes, including cell adhesion, migration, proliferation, and differentiation.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Lysyl oxidase homolog 3 | A lysyl oxidase homolog 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P58215] | Homo sapiens (human) |
Compounds (4)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| pyrithione | pyrithione : A pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent. pyrithione: split from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes; RN given refers to parent cpd; structure | monohydroxypyridine; pyridinethione | ionophore |
| aminopropionitrile | Aminopropionitrile: Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid. | aminopropionitrile | antineoplastic agent; antirheumatic drug; collagen cross-linking inhibitor; plant metabolite |
| disulfiram | organic disulfide; organosulfur acaricide | angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 3.1.1.1 (carboxylesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; ferroptosis inducer; fungicide; NF-kappaB inhibitor | |
| thiram | thiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment. Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations. | organic disulfide | antibacterial drug; antifungal agrochemical; antiseptic drug |