regulation of plasma membrane repair

Definition

Target type: biologicalprocess

Any process that modulates the frequency, rate or extent of plasma membrane repair. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]

Plasma membrane repair is a crucial cellular process that ensures the integrity of the cell's outer boundary. This process is essential for maintaining cellular homeostasis and preventing the leakage of vital cellular components. Damage to the plasma membrane can be caused by a variety of factors, including mechanical injury, exposure to toxins, and pathogen attack. The cellular response to plasma membrane damage involves a complex interplay of signaling pathways, protein recruitment, and membrane trafficking events. The process can be broadly divided into three main phases: 1) **Sensing and signaling:** Damaged membrane triggers the activation of signaling pathways, including the recruitment of lipid kinases and phospholipases. These molecules generate lipid messengers, such as phosphatidylinositol 3,4,5-trisphosphate (PIP3), which act as second messengers and recruit downstream effectors. 2) **Membrane resealing:** Activated signaling pathways lead to the recruitment and activation of repair proteins, such as actin-binding proteins, membrane-associated proteins, and calcium-dependent enzymes. These proteins contribute to the sealing of the membrane breach. This phase involves the formation of a transient membrane patch, called the "actin cap", at the site of damage. This actin cap acts as a barrier, preventing further leakage and facilitating membrane repair. 3) **Membrane repair and restoration:** Following the initial sealing, the plasma membrane undergoes repair and restoration. This involves the fusion of internal membrane vesicles, called "endosomes", with the damaged region. This fusion delivers lipids and proteins to the damaged area, promoting membrane repair and restoring the structural integrity of the plasma membrane. The precise mechanisms of membrane repair vary depending on the type and severity of the damage. However, the process generally involves a coordinated effort of signaling pathways, protein recruitment, and membrane trafficking events, all aimed at maintaining the integrity of the plasma membrane and ensuring cell survival.'
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Proteins (1)

Compounds (1)