positive regulation of telomerase RNA localization to Cajal body

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]

Telomerase RNA (TERC) localization to the Cajal body is a crucial step in the regulation of telomere maintenance. The Cajal body is a nuclear structure involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome. Telomerase, a ribonucleoprotein complex, requires TERC for its activity, and its localization to the Cajal body is thought to be important for its assembly and stability.

The positive regulation of TERC localization to the Cajal body involves a complex interplay of factors, including:

1. **TERC structure:** TERC contains specific sequences that are recognized by proteins involved in Cajal body localization. The Cajal body localization signal (CBLS) within TERC has been identified and is crucial for its targeting to the Cajal body.

2. **Protein interactions:** Proteins such as NOP10 and GAR1 interact with TERC and facilitate its transport to the Cajal body. NOP10 is a nucleolar protein that binds to TERC and acts as a chaperone, promoting its association with GAR1. GAR1 is a Cajal body-specific protein that interacts with both NOP10 and TERC, guiding the complex to the Cajal body.

3. **Cajal body components:** Cajal bodies contain specific factors that are important for TERC localization, such as coilin, a scaffolding protein that forms the structural framework of the Cajal body. Coilin interacts with GAR1, stabilizing the complex and contributing to TERC localization.

4. **RNA modifications:** TERC undergoes specific modifications, including pseudouridylation and methylation, which are important for its stability and Cajal body localization. These modifications can affect TERC interactions with proteins involved in Cajal body targeting.

5. **Transcriptional regulation:** The transcription of TERC is tightly regulated, and its expression levels can influence its localization to the Cajal body. This regulation involves specific transcription factors that bind to the TERC promoter.

6. **Cellular context:** The localization of TERC to the Cajal body can be influenced by cellular context, including cell type, developmental stage, and cellular stress.

The positive regulation of TERC localization to the Cajal body ensures proper telomerase assembly and function, contributing to the maintenance of telomere length and genomic stability.'
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Proteins (2)

Compounds (3)