Page last updated: 2024-10-24

cellular response to 1-oleoyl-sn-glycerol 3-phosphate

Definition

Target type: biologicalprocess

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:12139919]

Cellular response to 1-oleoyl-sn-glycerol 3-phosphate is a complex biological process involving a cascade of events triggered by the interaction of 1-oleoyl-sn-glycerol 3-phosphate (1-OG) with cellular receptors and signaling pathways. 1-OG, a lysophospholipid, acts as a signaling molecule in various cellular processes, including cell growth, differentiation, and migration.

Upon binding to its specific receptors, 1-OG initiates a signaling cascade that involves activation of downstream kinases and phosphatases, leading to alterations in gene expression, protein synthesis, and cellular behavior.

The specific downstream effects of 1-OG signaling vary depending on the cell type and context. In some cases, 1-OG may promote cell proliferation and survival, while in others, it may induce apoptosis or differentiation.

The cellular response to 1-OG is influenced by a variety of factors, including the concentration of 1-OG, the expression levels of its receptors, and the presence of other signaling molecules.

The detailed mechanisms of 1-OG signaling are still being investigated, but the process is known to involve the activation of several key signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway, the phosphatidylinositol 3-kinase (PI3K) pathway, and the protein kinase C (PKC) pathway.

The activation of these pathways leads to a variety of cellular responses, including changes in gene expression, protein synthesis, and cellular metabolism.

The response to 1-OG is crucial for a wide range of physiological processes, including development, immunity, and wound healing. Understanding the details of this process is therefore important for the development of novel therapeutic strategies for diseases such as cancer and inflammation.'
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Proteins (1)

ProteinDefinitionTaxonomy
Lysophosphatidic acid receptor 1A lysophosphatidic acid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q92633]Homo sapiens (human)

Compounds (6)

CompoundDefinitionClassesRoles
dioctanoylphosphatidic aciddioctanoylphosphatidic acid: structure given in first source1,2-diacyl-sn-glycerol 3-phosphate;
octanoate ester
lysophosphatidic acid1-oleoyl-sn-glycerol 3-phosphate : A 1-acyl-sn-glycerol 3-phosphate having oleoyl as the 1-O-acyl group.

lysophosphatidic acid : A member of the class of lysophosphatidic acids obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid. A 'closed' class.

lysophosphatidic acid: RN given refers to parent cpd
1-acyl-sn-glycerol 3-phosphate
lysophosphatidic acid
diacylglycerol pyrophosphate1,2-dioctanoyl-sn-glycerol 3-diphosphate : A 1,2-diacyl-sn-glycerol 3-diphosphate in which both of the phosphatidyl acyl groups are specified as octanoyl.1,2-diacyl-sn-glycerol 3-diphosphate;
octanoate ester
ki164253-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid : A member of the class of isoxazoles that is the carbamate ester obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)ethyl hydrogen carbonate with the amino group of 3-({[4-(4-amino-3-methyl-1,2-oxazol-5-yl)phenyl]methyl}sulfanyl)propanoic acid.carbamate ester;
isoxazoles;
monocarboxylic acid;
monochlorobenzenes;
organic sulfide
vpc32183VPC32183: lysophosphatidic acid (LPA) receptor antagonist