response to 11-deoxycorticosterone

Definition

Target type: biologicalprocess

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]

Response to 11-deoxycorticosterone is a complex biological process initiated by the binding of this steroid hormone to its specific receptor, the mineralocorticoid receptor (MR). This interaction triggers a cascade of events that ultimately lead to changes in gene expression and cellular function. Here's a detailed breakdown of the process:

**1. Hormone Binding:**
- 11-deoxycorticosterone (DOC) diffuses across the cell membrane and binds to the MR within the cytoplasm.
- This binding is highly specific and initiates a conformational change in the MR, causing it to dissociate from chaperone proteins that normally keep it inactive.

**2. Nuclear Translocation:**
- The activated MR-DOC complex translocates to the nucleus, where it interacts with specific DNA sequences called mineralocorticoid response elements (MREs).

**3. Transcriptional Regulation:**
- Binding of the MR-DOC complex to MREs triggers the recruitment of co-activator proteins, leading to the activation of target genes.
- This results in the increased transcription and translation of proteins involved in various cellular processes, including:
- **Sodium and Potassium Homeostasis:** DOC's primary role is in regulating electrolyte balance. It promotes sodium reabsorption and potassium excretion by activating genes for sodium channels and potassium pumps in the kidneys.
- **Blood Pressure Regulation:** The electrolyte changes mediated by DOC contribute to blood pressure regulation by influencing blood volume and vascular tone.
- **Cardiovascular Function:** DOC can have effects on heart function, influencing contractility and heart rate.
- **Inflammation and Immune Response:** DOC has been implicated in inflammatory processes and may influence immune cell function.
- **Stress Response:** DOC plays a role in the body's response to stress, interacting with the hypothalamic-pituitary-adrenal (HPA) axis.

**4. Cellular Response:**
- The newly transcribed proteins ultimately alter cellular function, leading to the specific physiological effects of DOC.

**5. Negative Feedback:**
- The increased levels of DOC can trigger a negative feedback loop, reducing the production of DOC by the adrenal glands to maintain hormone homeostasis.

This is a simplified outline of the biological processes involved in response to 11-deoxycorticosterone. The specific effects of DOC can vary depending on the target tissue, the concentration of the hormone, and other factors.'
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Proteins (1)

Compounds (2)