response to dehydroepiandrosterone

Definition

Target type: biologicalprocess

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus. [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]

Dehydroepiandrosterone (DHEA) is a steroid hormone produced primarily by the adrenal glands. It is a precursor to testosterone and estrogen and plays a role in various physiological processes, including immune function, brain health, and energy metabolism. The response to DHEA is complex and involves multiple signaling pathways and cellular processes.

Upon entering the cell, DHEA can bind to various receptors, including the androgen receptor (AR), estrogen receptor (ER), and the peroxisome proliferator-activated receptor alpha (PPARα). Binding to these receptors triggers downstream signaling cascades that lead to a range of cellular responses.

1. **Androgen Receptor Signaling:** DHEA can bind to the AR, although with lower affinity than testosterone. Activation of the AR by DHEA can promote protein synthesis, cell growth, and differentiation.

2. **Estrogen Receptor Signaling:** DHEA can be converted to estradiol, a potent estrogen, via aromatase. Binding to the ER can modulate gene expression, leading to effects on reproductive function, bone health, and cardiovascular health.

3. **PPARα Activation:** DHEA can activate PPARα, a nuclear receptor involved in lipid metabolism. Activation of PPARα promotes fatty acid oxidation and reduces triglyceride levels.

4. **Other Signaling Pathways:** DHEA can also interact with other signaling pathways, such as the insulin-like growth factor (IGF) pathway and the mitogen-activated protein kinase (MAPK) pathway.

The response to DHEA varies depending on the target tissue, age, and gender. For example, DHEA has been shown to improve cognitive function in aging individuals, enhance immune function in older adults, and promote muscle growth in athletes.

However, it is important to note that high levels of DHEA can have negative effects. It can contribute to acne, hair loss, and increased risk of prostate cancer. Additionally, DHEA supplementation is not recommended for all individuals and should be discussed with a healthcare professional.'
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Proteins (1)

Compounds (2)