regulation of transcription of nucleolar large rRNA by RNA polymerase I

Definition

Target type: biologicalprocess

Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I. [GOC:sart, GOC:TermGenie]

Regulation of transcription of nucleolar large rRNA by RNA polymerase I is a complex process that involves a series of coordinated steps. The process begins with the assembly of a pre-initiation complex (PIC) at the promoter of the rRNA gene. The PIC consists of RNA polymerase I, the transcription factors UBF and SL1, and the upstream binding factor (UBF). UBF is a DNA-binding protein that binds to the upstream control element (UCE) of the rRNA gene. SL1 is a complex of four proteins that binds to the core promoter. The binding of these factors is essential for the recruitment of RNA polymerase I to the promoter and the initiation of transcription. Once RNA polymerase I is bound to the promoter, it begins to transcribe the rRNA gene. The transcribed RNA is then processed and assembled into ribosomes. The regulation of transcription of nucleolar large rRNA by RNA polymerase I is essential for the synthesis of ribosomes, which are the protein synthesis machinery of the cell. Several factors can regulate the activity of RNA polymerase I, including the availability of transcription factors, the phosphorylation state of RNA polymerase I, and the presence of specific signaling pathways. The regulation of RNA polymerase I activity is important for ensuring that the cell produces the correct amount of ribosomes to meet its needs. '
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Proteins (1)

Compounds (2)