positive regulation of strand invasion

Definition

Target type: biologicalprocess

Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. [GOC:dos, GOC:dph, GOC:elh, GOC:tb]

Positive regulation of strand invasion is a critical step in homologous recombination (HR), a major DNA repair pathway that ensures genomic stability. HR involves the exchange of genetic information between two similar DNA molecules, allowing for the repair of damaged DNA sequences. Strand invasion is a crucial step in HR, where a single-stranded DNA molecule (the invading strand) displaces a homologous strand in a double-stranded DNA molecule (the target DNA). This process is mediated by the RecA protein in bacteria and its homologs in eukaryotes, known as Rad51 and Dmc1. These proteins bind to the invading strand and facilitate the search for homology between the invading strand and the target DNA. Upon finding homology, the invading strand displaces one of the strands in the target DNA, forming a D-loop structure. This displacement is facilitated by the RecA protein, which acts as a molecular motor to unwind the target DNA and displace the homologous strand. The formation of the D-loop structure provides a template for DNA synthesis, allowing the damaged DNA to be repaired using the homologous sequence as a guide. The positive regulation of strand invasion can be influenced by various factors, including the presence of specific DNA sequences, the availability of co-factors, and the activity of other DNA repair proteins. These factors contribute to the efficiency and fidelity of the strand invasion process, ensuring accurate and precise repair of damaged DNA sequences.'
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Proteins (1)

Compounds (2)