metanephric interstitial fibroblast development

Definition

Target type: biologicalprocess

The process whose specific outcome is the progression of a metanephric interstitial fibroblast over time, from its formation to the mature structure. [GOC:mtg_kidney_jan10]

Metanephric interstitial fibroblast development is a complex and tightly regulated process that plays a crucial role in the formation of the functional kidney. It involves a series of events orchestrated by a diverse array of signaling molecules, transcription factors, and extracellular matrix components.

The metanephric mesenchyme, a specialized tissue surrounding the ureteric bud, gives rise to the interstitial fibroblasts. These fibroblasts are essential for the formation of the renal interstitium, the space between the nephrons and blood vessels. They contribute to the establishment of the correct kidney architecture by providing structural support, secreting extracellular matrix components, and participating in the formation of the peritubular capillaries.

The process of metanephric interstitial fibroblast development begins with the interaction between the ureteric bud and the metanephric mesenchyme. The ureteric bud, an outgrowth from the Wolffian duct, releases signaling molecules such as glial cell line-derived neurotrophic factor (GDNF) that induce mesenchymal cells to differentiate into interstitial fibroblasts.

GDNF signaling activates downstream pathways, leading to the expression of transcription factors such as Pax2 and Six2. These transcription factors are crucial for mesenchymal cell proliferation and differentiation.

As the metanephric mesenchyme differentiates, it undergoes a mesenchymal-to-epithelial transition (MET), giving rise to the nephrons. The interstitial fibroblasts, derived from the remaining mesenchyme, form a network around the developing nephrons and blood vessels.

The interstitial fibroblasts produce a diverse array of extracellular matrix components, including collagen, fibronectin, and laminin, which contribute to the formation of the interstitial space and provide structural support for the kidney. They also play a role in the development of the peritubular capillaries by secreting factors that promote angiogenesis.

Furthermore, interstitial fibroblasts are involved in regulating the function of the nephrons by secreting factors that influence tubular transport and blood flow. They express a variety of receptors for hormones and growth factors, enabling them to respond to changes in the renal environment and adjust their activity accordingly.

In summary, metanephric interstitial fibroblast development is an intricate process involving multiple signaling pathways, transcription factors, and extracellular matrix components. This process is essential for the formation of the functional kidney and contributes to the proper development and function of the renal interstitium and peritubular capillaries.'
"

Proteins (1)

Compounds (1)