metanephric glomerulus vasculature development

Definition

Target type: biologicalprocess

The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus. [GOC:mtg_kidney_jan10]

The development of the metanephric glomerulus vasculature is a complex process involving the coordinated interplay of various signaling pathways and cell types. It begins with the formation of the nephric mesenchyme, which originates from the intermediate mesoderm. Within this mesenchyme, a group of cells differentiate into podocytes, which are specialized epithelial cells that form the filtration barrier of the glomerulus. Concurrently, endothelial cells from the surrounding capillaries migrate towards the forming glomerulus, forming the glomerular capillary network. This migration is guided by chemoattractants secreted by the podocytes, such as vascular endothelial growth factor (VEGF). VEGF signaling stimulates endothelial cell proliferation and migration, and also promotes the formation of new blood vessels. Once the endothelial cells reach the forming glomerulus, they form a network of capillaries that intertwine with the podocytes. These capillaries are supported by a specialized extracellular matrix, composed of laminin, collagen IV, and other proteins, which is essential for the stability and function of the glomerulus. The development of the glomerular vasculature is also influenced by factors from the surrounding mesenchyme, including platelet-derived growth factor (PDGF), which stimulates the proliferation and differentiation of smooth muscle cells that surround the capillaries, forming the pericytes. Pericytes provide structural support and regulate capillary blood flow. As the glomerulus matures, the capillaries become fenestrated, meaning they develop small pores that allow for the filtration of blood plasma. This process is regulated by several factors, including VEGF, fibroblast growth factor (FGF), and transforming growth factor beta (TGF-β). In addition to the vascular network, the glomerulus also contains a specialized structure called the mesangium. The mesangial cells are located within the glomerular capillaries and are responsible for regulating blood flow and filtering waste products. The development of the mesangium is influenced by PDGF and other growth factors. In summary, the development of the metanephric glomerulus vasculature is a complex process involving the coordinated interplay of multiple signaling pathways and cell types, ultimately leading to the formation of a specialized network of capillaries that facilitates blood filtration in the kidney.'
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Compounds (2)