metanephric proximal straight tubule development

Definition

Target type: biologicalprocess

The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule. [GOC:mtg_kidney_jan10]

Metanephric proximal straight tubule development is a complex process that begins with the formation of the metanephric kidney, which is the primary excretory organ in mammals. The metanephric kidney develops from two structures: the metanephric mesenchyme, which arises from the intermediate mesoderm, and the ureteric bud, which is an outgrowth of the Wolffian duct.

The ureteric bud invades the metanephric mesenchyme, inducing the mesenchyme to differentiate into epithelial cells. These epithelial cells then form nephrons, the functional units of the kidney. Each nephron consists of a glomerulus, a proximal convoluted tubule, a loop of Henle, a distal convoluted tubule, and a collecting duct.

The proximal straight tubule is a segment of the nephron that connects the proximal convoluted tubule to the loop of Henle. It is characterized by its straight shape and its location in the renal medulla. The proximal straight tubule plays a key role in the reabsorption of water and solutes from the filtrate, and it also contributes to the regulation of blood pressure.

The development of the proximal straight tubule is a highly regulated process that involves the interplay of several signaling pathways. These pathways include the Wnt signaling pathway, the FGF signaling pathway, and the BMP signaling pathway.

The Wnt signaling pathway is essential for the formation of the metanephric mesenchyme and for the induction of nephron formation. The FGF signaling pathway is involved in the growth and differentiation of the ureteric bud. The BMP signaling pathway is involved in the regulation of nephron development, including the formation of the proximal straight tubule.

In addition to these signaling pathways, several transcription factors are also involved in the development of the proximal straight tubule. These transcription factors include Pax2, Six2, and Gata3.

Pax2 is a transcription factor that is essential for the development of the metanephric kidney and for the formation of nephrons. Six2 is a transcription factor that is involved in the regulation of nephron development and in the maintenance of the metanephric mesenchyme. Gata3 is a transcription factor that is involved in the differentiation of proximal tubule cells.

The development of the proximal straight tubule is a complex process that requires the coordinated action of multiple signaling pathways and transcription factors. This process is essential for the proper function of the kidney and for the overall health of the organism.'
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