podosome assembly

Definition

Target type: biologicalprocess

The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. [GOC:mah, GOC:sl]

Podosome assembly is a complex process that involves the coordinated interplay of multiple cellular components, including actin filaments, focal adhesion proteins, and signaling molecules. It begins with the nucleation of actin filaments at the plasma membrane, often triggered by specific signaling pathways. These nascent actin filaments then elongate and bundle together to form the core of the podosome. The actin network is tightly regulated by various actin-binding proteins, including Arp2/3 complex, formin, and capping proteins, which control its branching, elongation, and stability.

As the actin core grows, it recruits focal adhesion proteins, such as vinculin, talin, and paxillin, which link the podosome to the extracellular matrix. These proteins also serve as scaffolding platforms for signaling molecules, such as Src kinases, PI3 kinases, and Rho GTPases, which regulate podosome formation and function.

The podosome is further stabilized by a ring of actin-associated proteins, including cortactin and WASp, which promote the formation of a dense network of actin filaments. This ring structure provides structural support and helps to create a distinct invagination of the plasma membrane, forming the characteristic cup-like structure of the podosome.

The assembly of podosomes is often driven by specific cellular signals, including growth factors, chemokines, and adhesion to extracellular matrix components. These signals activate signaling cascades that lead to the recruitment and activation of key regulators of podosome formation, such as Rho GTPases and Src kinases.

In addition to its role in cell adhesion and migration, podosomes have also been implicated in a variety of other cellular processes, including matrix degradation, cell invasion, and immune cell function. Their dynamic nature and ability to remodel the extracellular matrix make them essential for a range of cellular functions.'
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Proteins (1)

Compounds (2)