inositol phosphate catabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:mah]

Inositol phosphate catabolism is a fundamental process that regulates various cellular functions, including signal transduction, membrane trafficking, and cellular growth. Inositol phosphates are phosphorylated derivatives of inositol, a sugar molecule with six hydroxyl groups. They serve as intracellular messengers, mediating the actions of a wide range of signaling molecules, including hormones, neurotransmitters, and growth factors.

The catabolic process of inositol phosphates involves a series of enzymatic reactions that remove phosphate groups from the inositol ring. This process is tightly regulated and involves specific enzymes with distinct substrate specificities.

One of the key enzymes involved in inositol phosphate catabolism is inositol polyphosphate 5-phosphatase (IPP5), which hydrolyzes the 5-phosphate group from various inositol phosphate isomers. Other enzymes, such as inositol monophosphatase (IMPase) and inositol pyrophosphatase (IPPase), also contribute to the breakdown of inositol phosphates.

The catabolic process of inositol phosphates leads to the generation of different inositol phosphate intermediates, which can be further metabolized or recycled back into the inositol phosphate signaling pathway.

The regulation of inositol phosphate catabolism is crucial for maintaining cellular homeostasis. Dysregulation of this process can lead to various cellular abnormalities and diseases. For example, mutations in the IPP5 gene are associated with neurodevelopmental disorders, while defects in IMPase activity have been implicated in various metabolic disorders.

In summary, inositol phosphate catabolism is a complex and tightly regulated process that plays a crucial role in various cellular functions. It involves a series of enzymatic reactions that remove phosphate groups from inositol phosphates, generating different intermediates that can be further metabolized or recycled back into the signaling pathway. Proper regulation of this process is essential for maintaining cellular homeostasis and preventing various diseases.'
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Proteins (1)

Compounds (8)