Target type: biologicalprocess
The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis. [GOC:ai, GOC:expert_rg, GOC:tb]
Meiotic spindle midzone assembly is a critical process during meiosis that ensures proper chromosome segregation and formation of daughter cells. It involves the coordinated assembly of microtubule bundles and associated proteins at the equator of the meiotic spindle, forming a structure known as the midzone. This midzone acts as a platform for the formation of the central spindle, which is essential for cytokinesis, the division of the cytoplasm.
The assembly of the meiotic spindle midzone begins during anaphase, as the chromosomes are pulled apart to opposite poles of the spindle. During this process, microtubules emanating from the poles of the spindle, called astral microtubules, start to overlap and bundle at the spindle equator. This overlap and bundling is facilitated by microtubule-associated proteins (MAPs), such as PRC1, MAP4K3, and NuMA.
As the midzone assembles, it recruits other proteins that contribute to the formation of the central spindle. One important protein is centralspindlin, a complex of proteins that includes the motor protein MKLP1 and the scaffold protein CYK-4. Centralspindlin is essential for the stabilization of the midzone microtubules and the recruitment of other proteins, including the contractile ring proteins, which are involved in cytokinesis.
The meiotic spindle midzone also plays a role in the formation of the midbody, a structure that connects the two daughter cells after cytokinesis. The midbody is formed by the fusion of the central spindle and the contractile ring. It contains proteins involved in the final separation of the daughter cells, such as the motor protein myosin II.
The proper assembly of the meiotic spindle midzone is essential for accurate chromosome segregation and the formation of viable daughter cells. Defects in midzone assembly can lead to aneuploidy, a condition characterized by an abnormal number of chromosomes, which can have serious consequences for the developing organism.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Inner centromere protein | An inner centromere protein that is encoded in the genome of human. [PRO:KER] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| amrinone | amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure. Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. | bipyridines | EC 3.1.4.* (phosphoric diester hydrolase) inhibitor |
| milrinone | bipyridines; nitrile; pyridone | cardiotonic drug; EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor; platelet aggregation inhibitor; vasodilator agent | |
| tak-901 | |||
| mk 5108 | aromatic ether | ||
| mln 8237 | MLN 8237: an aurora kinase A inhibitor | benzazepine | |
| gsk 1070916 | GSK 1070916: an antineoplastic agent with aurora B/C kinase inhibitory activity | pyrazoles; ring assembly | |
| cfi-400945 |