L-cysteine catabolic process to pyruvate

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate. [GOC:go_curators]

The L-cysteine catabolic process to pyruvate is a complex metabolic pathway that involves several enzymes and cofactors. The process begins with the transamination of L-cysteine to L-cystathionine by the enzyme cystathionine β-synthase, which requires pyridoxal phosphate as a cofactor. L-cystathionine is then cleaved to α-ketobutyrate and cysteine by cystathionine γ-lyase. α-Ketobutyrate is further metabolized to propionyl-CoA by the enzyme α-ketobutyrate dehydrogenase complex. Propionyl-CoA is then converted to succinyl-CoA through a series of reactions involving propionyl-CoA carboxylase, methylmalonyl-CoA mutase, and succinyl-CoA synthetase. Succinyl-CoA is a key intermediate in the citric acid cycle, and its formation from L-cysteine ultimately leads to the production of pyruvate. Pyruvate can then be used as a substrate for various metabolic processes, including gluconeogenesis, the synthesis of amino acids, and energy production via the tricarboxylic acid cycle.'
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Proteins (2)

Compounds (1)