coenzyme A biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. [ISBN:0198547684]

Coenzyme A (CoA) biosynthesis is a vital metabolic pathway that produces coenzyme A, an essential cofactor for numerous enzymatic reactions. These reactions encompass a wide range of metabolic processes, including carbohydrate metabolism, lipid metabolism, and amino acid metabolism. The biosynthesis of CoA begins with the conversion of pantothenate (vitamin B5) into pantothenic acid, which is subsequently phosphorylated by pantothenate kinase. The resulting 4'-phosphopantothenate undergoes a series of enzymatic reactions involving cysteine, adenosine triphosphate (ATP), and dephospho-CoA kinase to form CoA. The initial steps of CoA biosynthesis involve the condensation of pantothenic acid and cysteine to form pantothenoylcysteine, followed by the addition of a phosphate group from ATP. The resulting 4'-phosphopantothenoylcysteine is then adenylated with ATP, forming dephospho-CoA. Finally, dephospho-CoA kinase catalyzes the phosphorylation of dephospho-CoA to produce CoA. This complex multi-step process ensures the availability of CoA, a crucial component for various metabolic reactions.'
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Proteins (2)

Compounds (2)