Page last updated: 2024-10-24

ATP transport

Definition

Target type: biologicalprocess

The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]

ATP transport is a fundamental process in cellular energy metabolism, involving the movement of adenosine triphosphate (ATP) across biological membranes. ATP is the primary energy currency of cells, providing the energy required for various cellular functions, including muscle contraction, nerve impulse transmission, and protein synthesis.

ATP transport is mediated by specific transmembrane proteins known as ATP transporters. These proteins exhibit high selectivity for ATP and facilitate its movement across the membrane in a controlled and energy-dependent manner.

The mechanism of ATP transport varies depending on the type of transporter and the cellular context. In some cases, ATP transport is coupled to the movement of other molecules, such as protons or sodium ions. This coupling allows for the establishment of electrochemical gradients across the membrane, which can be harnessed to drive other cellular processes.

**Here are some key aspects of ATP transport:**

* **Active transport:** ATP transport is an active process, meaning it requires energy. This is because ATP is transported against its concentration gradient, from an area of low concentration to an area of high concentration.
* **Specificity:** ATP transporters are highly specific for ATP. They recognize and bind to ATP with high affinity, ensuring that only ATP is transported across the membrane.
* **Regulation:** ATP transport is tightly regulated to meet the energy demands of the cell. The activity of ATP transporters can be influenced by factors such as cellular energy levels, hormonal signals, and environmental conditions.

**Examples of ATP transport:**

* **Mitochondrial ATP transport:** Mitochondria, the powerhouses of cells, produce ATP through oxidative phosphorylation. ATP generated in the mitochondrial matrix needs to be transported to the cytoplasm for use by other cellular processes. This is accomplished by the mitochondrial adenine nucleotide translocase (ANT), a protein that exchanges ATP for ADP across the mitochondrial inner membrane.
* **Plasma membrane ATP transport:** Some cells, such as erythrocytes (red blood cells) and some bacteria, have ATP transporters located in their plasma membranes. These transporters allow for the export of ATP from the cell, potentially playing a role in energy exchange between cells or in the maintenance of cellular homeostasis.

ATP transport is a crucial process that ensures the efficient delivery of energy to all parts of the cell. It plays a vital role in maintaining cellular function and supporting life.'
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Proteins (1)

ProteinDefinitionTaxonomy
Pannexin-1A pannexin-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96RD7]Homo sapiens (human)

Compounds (1)

CompoundDefinitionClassesRoles
probenecidprobenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.

Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
benzoic acids;
sulfonamide
uricosuric drug