myotube cell development
Definition
Target type: biologicalprocess
The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:mtg_muscle]
Myotube cell development is a complex process involving a series of coordinated events that ultimately lead to the formation of functional muscle fibers. This process begins with the commitment of mesenchymal stem cells to the myogenic lineage. These committed cells, known as myoblasts, proliferate and migrate to the site of muscle formation. Once at the site, myoblasts undergo a series of changes, including the expression of muscle-specific proteins, such as myosin and actin, and the fusion of multiple myoblasts to form multinucleated myotubes. This fusion is essential for the formation of long, cylindrical muscle fibers. During myotube formation, the myoblasts align themselves in parallel, with their plasma membranes fusing to create a continuous syncytium. This process is regulated by cell adhesion molecules, such as cadherins and integrins. As the myotubes mature, they develop a complex internal structure, including sarcomeres, which are the basic contractile units of muscle fibers. The formation of sarcomeres requires the assembly of thick and thin filaments, composed of myosin and actin, respectively. These filaments are organized in a precise manner, with myosin filaments positioned in the center of the sarcomere and actin filaments extending from either end. This precise organization allows for the efficient contraction and relaxation of muscle fibers. The myotubes continue to differentiate and mature, becoming more specialized and acquiring the ability to contract. This process involves the expression of genes that encode proteins involved in muscle function, such as calcium-binding proteins and ion channels. Ultimately, the myotubes develop into fully functional muscle fibers, capable of generating force and contributing to movement.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Histone-lysine N-methyltransferase SMYD3 | A histone-lysine N-methyltransferase SMYD3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H7B4] | Homo sapiens (human) |
Compounds (2)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| scutellarein | scutellarein : Flavone substituted with hydroxy groups at C-4', -5, -6 and -7. scutellarein: aglycone of scutellarin from Scutellaria baicalensis; carthamidin is 2S isomer of scutellarein; do not confuse with isoscutellarein and/or isocarthamidin which are respective regioisomers, or with the scutelarin protein | tetrahydroxyflavone | metabolite |
| az 505 | AZ 505: an SMYD2 inhibitor; structure in first source |