Target type: biologicalprocess
An error-prone process for repairing damaged microbial DNA. [GOC:jl, PMID:16000023]
The SOS response is a global DNA damage response system found in bacteria, which allows them to survive potentially lethal DNA damage. The response is triggered by the accumulation of single-stranded DNA (ssDNA) that occurs when DNA replication is stalled by lesions. RecA protein, a DNA-dependent ATPase, binds to ssDNA and forms a nucleoprotein filament. This filament catalyzes the cleavage of LexA, a repressor protein that normally silences SOS genes. The LexA protein is also an autoprotease, meaning that it can cleave itself, leading to its inactivation. Cleavage of LexA removes repression of the SOS genes, allowing their transcription and translation. These genes encode proteins that are involved in DNA repair, error-prone DNA replication, and cell cycle regulation. One such gene encodes for RecA protein itself, making this a positive feedback loop that amplifies the SOS response. The SOS response is a complex and highly regulated process that involves a wide range of proteins and genes. It is essential for the survival of bacteria in the face of DNA damage, and it has also been implicated in bacterial evolution and antibiotic resistance.'
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Protein | Definition | Taxonomy |
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ATP-dependent DNA helicase DinG | An ATP-dependent DNA helicase DinG that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P27296] | Escherichia coli K-12 |
ATP-dependent DNA helicase DinG | An ATP-dependent DNA helicase DinG that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P27296] | Escherichia coli K-12 |
Cell division inhibitor SulA | A cell division inhibitor SulA that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AFZ5] | Escherichia coli K-12 |
Cell division inhibitor SulA | A cell division inhibitor SulA that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AFZ5] | Escherichia coli K-12 |
Compound | Definition | Classes | Roles |
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Telomestatin | 1,3-oxazoles | ||
novobiocin | novobiocin : A coumarin-derived antibiotic obtained from Streptomyces niveus. Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) | carbamate ester; ether; hexoside; hydroxycoumarin; monocarboxylic acid amide; monosaccharide derivative; phenols | antibacterial agent; antimicrobial agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Escherichia coli metabolite; hepatoprotective agent |
clorobiocin | clorobiocin: chlorine-containing antibiotic related to novobiocin |