chorismate biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds. [GOC:sm, ISBN:0198547684]

The chorismate biosynthetic process is a fundamental metabolic pathway in bacteria, fungi, and plants, which is responsible for the production of chorismate. Chorismate is a crucial precursor for the biosynthesis of several essential aromatic compounds, including the amino acids tryptophan, tyrosine, and phenylalanine, as well as the vitamins folate and ubiquinone. The pathway begins with the condensation of phosphoenolpyruvate (PEP) and erythrose 4-phosphate (E4P), catalyzed by the enzyme DAHP synthase. This reaction forms 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP). DAHP is then converted to chorismate through a series of seven enzymatic steps. These steps involve the sequential addition of a phosphate group, dehydration, isomerization, and decarboxylation. The enzymes involved in these steps include DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate kinase, shikimate dehydrogenase, 5-enolpyruvylshikimate 3-phosphate synthase, and chorismate synthase. The chorismate biosynthetic process is highly regulated to ensure that the production of aromatic compounds meets the needs of the organism. This regulation is achieved through a complex interplay of feedback inhibition and gene expression control.'
"

Proteins (1)

Compounds (2)