creatine metabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. [GOC:jl, ISBN:0192801023]

Creatine metabolism is a critical process for energy production in muscle cells. The process starts with the synthesis of creatine from the amino acids glycine, arginine, and methionine. This synthesis occurs mainly in the liver and kidneys. Creatine then travels to muscle cells, where it is phosphorylated to phosphocreatine by the enzyme creatine kinase. Phosphocreatine serves as a high-energy phosphate reservoir, providing a rapid source of energy for muscle contraction. When ATP levels in muscle cells decline, phosphocreatine is dephosphorylated, releasing energy that is used to regenerate ATP. During periods of high energy demand, such as during intense exercise, the creatine-phosphocreatine cycle plays a crucial role in maintaining ATP levels and enabling sustained muscle activity. Creatine metabolism is also involved in other cellular processes, including nerve impulse transmission and brain function. Creatine deficiency can lead to muscle weakness, fatigue, and neurological problems. Supplementation with creatine is often used by athletes and other individuals to enhance physical performance and cognitive function.'
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Proteins (2)

Compounds (1)