Target type: biologicalprocess
The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane. [GOC:dph, PMID:3886029]
| Protein | Definition | Taxonomy |
|---|---|---|
| Acrosin | An acrosin that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10323] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 2'-carbomethoxyphenyl 4-guanidinobenzoate | 2'-carbomethoxyphenyl 4-guanidinobenzoate: potent inhibitor of the sperm enzyme acrosin | ||
| tosyllysine chloromethyl ketone | Tosyllysine Chloromethyl Ketone: An inhibitor of SERINE ENDOPEPTIDASES. Acts as an alkylating agent and is known to interfere with the translation process. | sulfonic acid derivative |