trophectodermal cell fate commitment
Definition
Target type: biologicalprocess
The cell fate commitment of precursor cells that will become trophectoderm cells. [GOC:dph, ISBN:0124020607, ISBN:0198542771]
Trophectodermal (TE) cell fate commitment is a crucial developmental process that occurs during the early stages of mammalian embryogenesis. It involves a series of molecular events that lead to the differentiation of a subset of blastomeres into TE cells, which will ultimately give rise to the placenta.
The process of TE cell fate commitment is initiated by the expression of specific transcription factors and signaling pathways. One of the key transcription factors involved is Cdx2. Cdx2 is a homeobox gene that is expressed in the TE lineage and plays a crucial role in the repression of pluripotency genes and the activation of TE-specific genes.
Another important signaling pathway involved in TE cell fate commitment is the Wnt signaling pathway. Wnt signaling is activated in the TE lineage and promotes the expression of TE-specific genes.
During TE cell fate commitment, blastomeres undergo a series of morphological changes. They become polarized, with the apical side facing the blastocoel cavity and the basal side attached to the inner cell mass (ICM). This polarization is essential for the formation of the TE epithelium, which is a single layer of cells that surrounds the ICM.
The TE epithelium is then responsible for the formation of the placenta. The placenta is a vital organ that provides oxygen and nutrients to the developing embryo and removes waste products. TE cells also contribute to the formation of the chorion, which is the outermost layer of the fetal membranes.
In summary, TE cell fate commitment is a complex process that involves the coordinated expression of specific transcription factors and signaling pathways. It is essential for the formation of the placenta and the development of the embryo. The process of TE cell fate commitment is highly regulated and involves a series of molecular and cellular events that ensure the proper development of the embryo.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Transcriptional enhancer factor TEF-3 | A transcriptional enhancer factor TEF-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15561] | Homo sapiens (human) |
Compounds (3)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| flufenamic acid | flufenamic acid : An aromatic amino acid consisting of anthranilic acid carrying an N-(trifluoromethyl)phenyl substituent. An analgesic and anti-inflammatory, it is used in rheumatic disorders. Flufenamic Acid: An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16) | aromatic amino acid; organofluorine compound | antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug |
| niflumic acid | Niflumic Acid: An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. | aromatic carboxylic acid; pyridines | |
| pirlindole | pirlindole: RN given refers to parent cpd; synonym pyrazidol refers to mono-HCl; structure in Negwer, 5th ed, #2812 | carbazoles |