Target type: biologicalprocess
The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress. [GOC:add, PMID:12925704]
Plasma membrane repair is a critical cellular process that maintains cell integrity and prevents the leakage of intracellular contents. It involves a complex series of events that are triggered by disruptions in the plasma membrane, such as those caused by mechanical injury, oxidative stress, or pathogen attack.
The process begins with the rapid detection of the membrane breach, which is mediated by a variety of sensors, including proteins that bind to exposed phospholipids or detect changes in membrane tension. Upon sensing damage, these proteins initiate signaling cascades that activate downstream repair mechanisms.
One key component of membrane repair is the recruitment and assembly of repair proteins at the site of damage. These proteins include components of the cytoskeleton, such as actin filaments, as well as specialized membrane-binding proteins that help to stabilize the damaged area.
Another crucial aspect of repair is the delivery of membrane lipids to the damaged site. This is achieved through the mobilization of intracellular membrane pools, such as those from the endoplasmic reticulum or Golgi apparatus. These lipids are incorporated into the damaged membrane, helping to reseal the breach and restore the integrity of the cell.
In addition to these immediate repair mechanisms, cells also activate long-term repair processes, such as the synthesis and delivery of new membrane components. This ensures that the cell can fully recover from the damage and maintain its structural and functional integrity over time.
Plasma membrane repair is essential for the survival of cells and the proper functioning of tissues and organs. Defects in this process can lead to a variety of diseases, including genetic disorders, neurodegenerative conditions, and inflammatory diseases. Therefore, understanding the molecular mechanisms underlying membrane repair is crucial for developing new therapies for these debilitating conditions.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Sphingomyelin phosphodiesterase | [no definition available] | Bos taurus (cattle) |
| Myosin-9 | A myosin-9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35579] | Homo sapiens (human) |
| Sphingomyelin phosphodiesterase | A sphingomyelin phosphodiesterase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17405] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| chlorpromazine | chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety. Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup. | organochlorine compound; phenothiazines; tertiary amine | anticoronaviral agent; antiemetic; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; phenothiazine antipsychotic drug |
| fendiline | Fendiline: Coronary vasodilator; inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as antiarrhythmic and antianginal agents. | diarylmethane | |
| imipramine | imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom. Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group. | dibenzoazepine | adrenergic uptake inhibitor; antidepressant; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor |
| inositol 2,4,6-triphosphate | |||
| 2-(1-benzo[e]benzofuranyl)-N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]acetamide | naphthofuran | ||
| blister | blebbistatin : A pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase activity of non-muscle myosin II. blebbistatin: structure in first source | cyclic ketone; pyrroloquinoline; tertiary alcohol; tertiary alpha-hydroxy ketone | inhibitor |
| mangostin | alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. mangostin: xanthone from rind of Garcinia mangostana Linn. fruit | aromatic ether; phenols; xanthones | antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite |