box C/D snoRNP assembly

Definition

Target type: biologicalprocess

The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex. [GOC:krc]

Box C/D snoRNPs are essential components of ribosome biogenesis, playing a crucial role in guiding the modification of ribosomal RNAs (rRNAs). Their assembly is a complex process involving multiple steps, beginning with the transcription of the snoRNA gene. This newly synthesized snoRNA is then recognized by a protein complex, containing the essential proteins NOP56, NOP58, and Snu13, forming the early assembly intermediate. The box C/D snoRNA itself carries two conserved sequence motifs known as box C and box D. These motifs are crucial for the recruitment of the core snoRNP protein complex, which includes the methyltransferase fibrillarin and the RNA-binding proteins NOP1 and NOP56. This complex is formed through interactions between box C/D and the proteins, specifically between box C and NOP56, and between box D and fibrillarin. Once the core complex is assembled, it recruits other proteins such as NOP58 and Snu13, leading to the formation of the mature box C/D snoRNP. This mature complex then localizes to the nucleolus, where it interacts with the pre-rRNA, directing the methylation of specific nucleotides on the rRNA. This methylation process is essential for the proper folding and function of the rRNA, contributing to the assembly of functional ribosomes.'
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Proteins (2)

Compounds (3)