Potassium voltage-gated channel subfamily F member 1

A voltage-gated potassium channel KCNF1 that is encoded in the genome of human. []

Voltage-gated potassium channel subunit Kv5.1;
kH1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide	Homo sapiens (human)	IC50	54,954,100,000.0000	1	1

This protein enables 3 target(s):

Target	Category	Definition
potassium channel activity	molecular function	Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
voltage-gated potassium channel activity	molecular function	Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
ciliary base	cellular component	Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. [GOC:cilia, GOC:krc, PMID:22653444]

This protein is active in 1 target(s):

Target	Category	Definition
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is part of 1 target(s):

Target	Category	Definition
voltage-gated potassium channel complex	cellular component	A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah]

This protein is involved in 5 target(s):

Target	Category	Definition
potassium ion transport	biological process	The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
protein homooligomerization	biological process	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai]
non-motile cilium assembly	biological process	The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium. [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]
action potential	biological process	A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
potassium ion transmembrane transport	biological process	A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]