DCN1-like protein 1

A DCN1-like protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96GG9]

DCNL1;
DCUN1 domain-containing protein 1;
Defective in cullin neddylation protein 1-like protein 1;
Squamous cell carcinoma-related oncogene

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
5-(4-chlorophenyl)-4h-1,2,4-triazole-3-thiol	Homo sapiens (human)	IC50	10.0000	2	2
5-(4-methoxyphenyl)-1,2-dihydro-1,2,4-triazole-3-thione	Homo sapiens (human)	IC50	10.0000	2	2

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
cullin family protein binding	molecular function	Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). [GOC:ha, InterPro:IPR016158, PMID:18698375]
ubiquitin conjugating enzyme binding	molecular function	Binding to a ubiquitin conjugating enzyme, any of the E2 proteins. [GOC:vp]
ubiquitin-like protein binding	molecular function	Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein. [GOC:mah]

This protein is located in 4 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is part of 1 target(s):

Target	Category	Definition
ubiquitin ligase complex	cellular component	A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. [GOC:jh2, PMID:9529603]

This protein is involved in 4 target(s):

Target	Category	Definition
regulation of protein ubiquitination	biological process	Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]
regulation of protein neddylation	biological process	Any process that modulates the frequency, rate or extent of protein neddylation. [GOC:obol]
positive regulation of protein neddylation	biological process	Any process that activates or increases the frequency, rate or extent of protein neddylation. [GOC:obol]
protein neddylation	biological process	Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. [PMID:11698580]