Ubiquitin carboxyl-terminal hydrolase 13

A ubiquitin carboxyl-terminal hydrolase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92995]

Synonyms

EC 3.4.19.12;
Deubiquitinating enzyme 13;
Isopeptidase T-3;
ISOT-3;
Ubiquitin thioesterase 13;
Ubiquitin-specific-processing protease 13

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
spautin-1	Homo sapiens (human)	IC50	0.6000	1	1

Enables

This protein enables 11 target(s):

Target	Category	Definition
cysteine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
cysteine-type deubiquitinase activity	molecular function	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
ubiquitin protein ligase binding	molecular function	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
ubiquitin binding	molecular function	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. [GOC:ecd]
ubiquitin-like protein ligase binding	molecular function	Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. [GOC:jl]
protein-folding chaperone binding	molecular function	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443]
proteasome binding	molecular function	Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation. [GOC:mah]
BAT3 complex binding	molecular function	Binding to a BAT3 complex. [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23246001]
K48-linked deubiquitinase activity	molecular function	Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin. [GOC:bf, GOC:PARL, PMID:22970133]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 11 target(s):

Target	Category	Definition
regulation of DNA-templated transcription	biological process	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
autophagy	biological process	The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation. [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]
cell population proliferation	biological process	The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
regulation of autophagy	biological process	Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb]
melanocyte differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. [GOC:mah]
maintenance of unfolded protein	biological process	Maintaining a protein in an unfolded, soluble state. [GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, PMID:21636303]
protein stabilization	biological process	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai]
protein K63-linked deubiquitination	biological process	A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. [GOC:mah, PMID:19202061, PMID:19214193]
positive regulation of ERAD pathway	biological process	Any process that activates or increases the frequency, rate or extent of ERAD pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
protein deubiquitination	biological process	The removal of one or more ubiquitin groups from a protein. [GOC:ai]