Rho guanine nucleotide exchange factor 1

A Rho guanine nucleotide exchange factor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92888]

115 kDa guanine nucleotide exchange factor;
p115-RhoGEF;
p115RhoGEF;
Sub1.5

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
stictic acid	Homo sapiens (human)	IC50	187.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
guanyl-nucleotide exchange factor activity	molecular function	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
GTPase activator activity	molecular function	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
G protein-coupled receptor binding	molecular function	Binding to a G protein-coupled receptor. [GOC:ceb, GOC:dph]

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 3 target(s):

Target	Category	Definition
Rho protein signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal. [GOC:bf]
regulation of small GTPase mediated signal transduction	biological process	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:go_curators]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]