A voltage-gated potassium channel subfamily G member 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q8TAE7]
Voltage-gated potassium channel subunit Kv10.1;
Voltage-gated potassium channel subunit Kv6.3
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide | Homo sapiens (human) | IC50 | 54,954,100,000.0000 | 1 | 1 |
This protein enables 2 target(s):
Target | Category | Definition |
---|---|---|
delayed rectifier potassium channel activity | molecular function | Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. [GOC:mah, PMID:11343411, PMID:2462513] |
protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
This protein is located in 2 target(s):
Target | Category | Definition |
---|---|---|
endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is active in 1 target(s):
Target | Category | Definition |
---|---|---|
membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is part of 1 target(s):
Target | Category | Definition |
---|---|---|
voltage-gated potassium channel complex | cellular component | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah] |
This protein is involved in 3 target(s):
Target | Category | Definition |
---|---|---|
protein homooligomerization | biological process | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai] |
potassium ion transmembrane transport | biological process | A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah] |
action potential | biological process | A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] |