5'-3' exonuclease PLD3

A 5-3 exonuclease PLD3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8IV08]

Synonyms

EC 3.1.16.1;
Choline phosphatase 3;
HindIII K4L homolog;
Hu-K4;
Phosphatidylcholine-hydrolyzing phospholipase D3;
Phospholipase D3;
PLD 3

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Compounds (1)

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
thymidine 5'-4-nitrophenyl phosphate	Homo sapiens (human)	Km	1,352.0000	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
phospholipase D activity	molecular function	Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. [EC:3.1.4.4]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
single-stranded DNA 5'-3' DNA exonuclease activity	molecular function	Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. [GOC:ai, GOC:elh, PMID:20086101]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
lysosomal membrane	cellular component	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
early endosome membrane	cellular component	The lipid bilayer surrounding an early endosome. [GOC:pz]
late endosome membrane	cellular component	The lipid bilayer surrounding a late endosome. [GOC:pz]
lysosomal lumen	cellular component	The volume enclosed within the lysosomal membrane. [GOC:jl, PMID:15213228]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
immune system process	biological process	Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. [GO_REF:0000022, GOC:add]
DNA metabolic process	biological process	Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. [ISBN:0198506732]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
myotube differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:mtg_muscle]
regulation of cytokine production involved in inflammatory response	biological process	Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie]