A voltage-gated potassium channel KCNB1 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q14721]
Delayed rectifier potassium channel 1;
DRK1;
h-DRK1;
Voltage-gated potassium channel subunit Kv2.1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide | Homo sapiens (human) | IC50 | 54,954,100,000.0000 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| SNARE binding | molecular function | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. [PMID:12642621] |
| delayed rectifier potassium channel activity | molecular function | Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. [GOC:mah, PMID:11343411, PMID:2462513] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| outward rectifier potassium channel activity | molecular function | Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. [GOC:mah] |
| transmembrane transporter binding | molecular function | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372] |
| protein heterodimerization activity | molecular function | Binding to a nonidentical protein to form a heterodimer. [GOC:ai] |
This protein is located in 13 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| lateral plasma membrane | cellular component | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr] |
| axon | cellular component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
| dendrite | cellular component | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] |
| neuronal cell body membrane | cellular component | The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. [GOC:jl] |
| sarcolemma | cellular component | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732] |
| perikaryon | cellular component | The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
| cholinergic synapse | cellular component | A synapse that uses acetylcholine as a neurotransmitter. [GOC:dos] |
| postsynaptic specialization membrane | cellular component | The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos] |
| proximal dendrite | cellular component | The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma). [GOC:aruk, GOC:bc, PMID:16899232] |
This protein is active in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| axon | cellular component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
| neuronal cell body membrane | cellular component | The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. [GOC:jl] |
| dendrite membrane | cellular component | The portion of the plasma membrane surrounding a dendrite. [GOC:mah] |
| postsynaptic membrane | cellular component | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| voltage-gated potassium channel complex | cellular component | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah] |
This protein is involved in 22 target(s):
| Target | Category | Definition |
|---|---|---|
| action potential | biological process | A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] |
| vesicle docking involved in exocytosis | biological process | The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915] |
| glutamate receptor signaling pathway | biological process | The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:9131252] |
| positive regulation of norepinephrine secretion | biological process | Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. [GOC:dph, GOC:tb] |
| cellular response to nutrient levels | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:mah] |
| positive regulation of catecholamine secretion | biological process | Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. [GOC:mah] |
| glucose homeostasis | biological process | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators] |
| clustering of voltage-gated potassium channels | biological process | The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode. [PMID:11456440] |
| positive regulation of calcium ion-dependent exocytosis | biological process | Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. [GOC:go_curators] |
| negative regulation of insulin secretion | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. [GOC:ai] |
| response to axon injury | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] |
| protein homooligomerization | biological process | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. [GOC:ai] |
| cellular response to calcium ion | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:mah] |
| cellular response to glucose stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:mah] |
| potassium ion transmembrane transport | biological process | A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah] |
| protein localization to plasma membrane | biological process | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah] |
| positive regulation of protein targeting to membrane | biological process | Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:tb] |
| potassium ion export across plasma membrane | biological process | The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:11932440] |
| regulation of action potential | biological process | Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] |
| positive regulation of long-term synaptic depression | biological process | Any process that activates or increases the frequency, rate or extent of long term synaptic depression. [GOC:BHF, GOC:TermGenie] |
| response to L-glutamate | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus. [GOC:TermGenie, PMID:23574009] |
| regulation of motor neuron apoptotic process | biological process | Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. [GOC:mtg_apoptosis, GOC:obol] |