Glucokinase regulatory protein

A glucokinase regulatory protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14397]

Synonyms

GKRP;
Glucokinase regulator

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ro-28-1675	Homo sapiens (human)	Activity	0.2400	1	1
ro-28-1675	Homo sapiens (human)	Km	2,070.0000	2	2

Enables

This protein enables 7 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
kinase inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of a kinase. [GOC:mah]
fructose-6-phosphate binding	molecular function	Binding to fructose 6-phosphate. [GOC:mah]
glucose sensor activity	molecular function	Binding to and responding, e.g. by conformational change, to changes in the cellular level of glucose. [PMID:17470517]
carbohydrate binding	molecular function	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
enzyme inhibitor activity	molecular function	Binds to and stops, prevents or reduces the activity of an enzyme. [GOC:ai, GOC:ebc]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Involved In

This protein is involved in 8 target(s):

Target	Category	Definition
protein import into nucleus	biological process	The directed movement of a protein from the cytoplasm to the nucleus. [GOC:jl]
response to glucose	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:jl]
response to fructose	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. [GOC:jl]
negative regulation of glucokinase activity	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. [GOC:mah]
urate metabolic process	biological process	The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. [ISBN:0198506732]
triglyceride homeostasis	biological process	Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. [GOC:BHF, GOC:mah]
carbohydrate derivative metabolic process	biological process	The chemical reactions and pathways involving carbohydrate derivative. [GOC:TermGenie]
glucose homeostasis	biological process	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]

chemdatabank.com