A glucokinase regulatory protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14397]
GKRP;
Glucokinase regulator
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ro-28-1675 | Homo sapiens (human) | Activity | 0.2400 | 1 | 1 |
| ro-28-1675 | Homo sapiens (human) | Km | 2,070.0000 | 2 | 2 |
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| kinase inhibitor activity | molecular function | Binds to and stops, prevents or reduces the activity of a kinase. [GOC:mah] |
| fructose-6-phosphate binding | molecular function | Binding to fructose 6-phosphate. [GOC:mah] |
| glucose sensor activity | molecular function | Binding to and responding, e.g. by conformational change, to changes in the cellular level of glucose. [PMID:17470517] |
| carbohydrate binding | molecular function | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah] |
| enzyme binding | molecular function | Binding to an enzyme, a protein with catalytic activity. [GOC:jl] |
| enzyme inhibitor activity | molecular function | Binds to and stops, prevents or reduces the activity of an enzyme. [GOC:ai, GOC:ebc] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| protein import into nucleus | biological process | The directed movement of a protein from the cytoplasm to the nucleus. [GOC:jl] |
| response to glucose | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:jl] |
| response to fructose | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. [GOC:jl] |
| negative regulation of glucokinase activity | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. [GOC:mah] |
| urate metabolic process | biological process | The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. [ISBN:0198506732] |
| triglyceride homeostasis | biological process | Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. [GOC:BHF, GOC:mah] |
| carbohydrate derivative metabolic process | biological process | The chemical reactions and pathways involving carbohydrate derivative. [GOC:TermGenie] |
| glucose homeostasis | biological process | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators] |