Proteins > 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Page last updated: 2024-08-07 23:45:04
1-deoxy-D-xylulose 5-phosphate reductoisomerase
[no definition available]
Synonyms
DXP reductoisomerase;
EC 1.1.1.267;
1-deoxyxylulose-5-phosphate reductoisomerase;
2-C-methyl-D-erythritol 4-phosphate synthase
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| fosmidomycin | Mycobacterium tuberculosis H37Rv | Kd | 0.0400 | 1 | 1 |
The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.Journal of medicinal chemistry, , Aug-08, Volume: 56, Issue:15, 2013
IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters.Journal of medicinal chemistry, , Oct-24, Volume: 56, Issue:20, 2013
Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.Journal of medicinal chemistry, , Jul-14, Volume: 54, Issue:13, 2011
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis.The Journal of biological chemistry, , Jul-06, Volume: 282, Issue:27, 2007
The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.Journal of medicinal chemistry, , Jul-14, Volume: 54, Issue:13, 2011
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011