Proteins > 3-oxoacyl-[acyl-carrier-protein] synthase 3
Page last updated: 2024-08-07 16:57:00
3-oxoacyl-[acyl-carrier-protein] synthase 3
A beta-ketoacyl-[acyl-carrier-protein] synthase III that is encoded in the genome of Mycobacterium tuberculosis H37Rv. [OMA:P9WNG3, PRO:DNx]
Synonyms
EC 2.3.1.180;
3-oxoacyl-[acyl-carrier-protein] synthase III;
Beta-ketoacyl-ACP synthase III;
KAS III;
MtFabH
Research
Bioassay Publications (2)
Timeframe | Studies on this Protein(%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (1)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
thiolactomycin | Mycobacterium tuberculosis H37Rv | IC50 | 55.3333 | 3 | 3 |
Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 17, Issue:20, 2007
Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006