An arginase-2, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78540]
EC 3.5.3.1;
Arginase II;
Kidney-type arginase;
Non-hepatic arginase;
Type II arginase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| n(omega)-hydroxyarginine | Homo sapiens (human) | Ki | 1.6000 | 1 | 1 |
| Nomega-hydroxy-nor-l-arginine | Homo sapiens (human) | Ki | 0.0510 | 2 | 2 |
| (S)-2-amino-6-boronohexanoic acid | Homo sapiens (human) | IC50 | 2.1500 | 1 | 1 |
| (S)-2-amino-6-boronohexanoic acid | Homo sapiens (human) | Ki | 0.0085 | 2 | 2 |
| 2-amino-6-boronohexanoic acid | Homo sapiens (human) | IC50 | 1.9200 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| arginase activity | molecular function | Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea. [EC:3.5.3.1] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| manganese ion binding | molecular function | Binding to a manganese ion (Mn). [GOC:ai] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
This protein is involved in 20 target(s):
| Target | Category | Definition |
|---|---|---|
| urea cycle | biological process | The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate. [GOC:pde, GOC:vw, ISBN:0198506732] |
| ureteric bud development | biological process | The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. [GOC:go_curators] |
| adaptive immune response | biological process | An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149] |
| negative regulation of type 2 immune response | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. [GOC:add] |
| nitric oxide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. [GOC:ai] |
| striated muscle contraction | biological process | A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. [GOC:jl, GOC:mtg_muscle, ISBN:0198506732] |
| regulation of interleukin-1 beta production | biological process | Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah] |
| negative regulation of interleukin-13 production | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production. [GOC:mah] |
| negative regulation of interleukin-17 production | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. [GOC:add, GOC:mah, PMID:16482511] |
| negative regulation of tumor necrosis factor production | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. [GOC:mah, PMID:10891884, PMID:15560120] |
| innate immune response | biological process | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] |
| negative regulation of macrophage inflammatory protein 1 alpha production | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha. [GOC:mah] |
| negative regulation of chemokine (C-C motif) ligand 4 production | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4. [GOC:mah] |
| negative regulation of chemokine (C-C motif) ligand 5 production | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5. [GOC:mah] |
| negative regulation of defense response to bacterium | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. [GOC:TermGenie, PMID:22346749] |
| regulation of reactive oxygen species biosynthetic process | biological process | Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] |
| negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process. [GO_REF:0000058, GOC:TermGenie, PMID:24187568] |
| negative regulation of CD4-positive, alpha-beta T cell proliferation | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. [GOC:obol] |
| positive regulation of cellular senescence | biological process | Any process that activates or increases the frequency, rate or extent of cellular senescence. [GOC:BHF] |
| arginine catabolic process to ornithine | biological process | The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine. [GOC:go_curators] |