Protein S100-A10

A protein S100-A10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P60903]

Synonyms

Calpactin I light chain;
Calpactin-1 light chain;
Cellular ligand of annexin II;
S100 calcium-binding protein A10;
p10 protein;
p11

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
N-(3,4-dimethylphenyl)-2-[[5-[[(4,6-dimethyl-2-pyrimidinyl)thio]methyl]-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]thio]acetamide	Homo sapiens (human)	IC50	9.7750	1	2

Enables

This protein enables 5 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
transmembrane transporter binding	molecular function	Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]
calcium-dependent protein binding	molecular function	Binding to a protein or protein complex in the presence of calcium. [GOC:jid, PMID:10485905]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
nuclear matrix	cellular component	The dense fibrillar network lying on the inner side of the nuclear membrane. [ISBN:0582227089]
collagen-containing extracellular matrix	cellular component	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 3 target(s):

Target	Category	Definition
RNA polymerase II transcription regulator complex	cellular component	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]
plasma membrane protein complex	cellular component	Any protein complex that is part of the plasma membrane. [GOC:dos]
AnxA2-p11 complex	cellular component	A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10). [GOC:bf, GOC:BHF, GOC:nc, PMID:18799458, PMID:23483454]

Involved In

This protein is involved in 13 target(s):

Target	Category	Definition
membrane raft assembly	biological process	The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes. [PMID:12648772, PMID:12803918, PMID:16645198]
vesicle budding from membrane	biological process	The evagination of a membrane, resulting in formation of a vesicle. [GOC:jid, GOC:tb]
positive regulation of plasminogen activation	biological process	Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin. [GOC:BHF, GOC:dph, GOC:tb]
mRNA transcription by RNA polymerase II	biological process	The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. [GOC:jl, ISBN:0321000382]
positive regulation of GTPase activity	biological process	Any process that activates or increases the activity of a GTPase. [GOC:jl, GOC:mah]
positive regulation of exocytosis	biological process	Any process that activates or increases the frequency, rate or extent of exocytosis. [GOC:go_curators]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
regulation of neurogenesis	biological process	Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. [GOC:ai]
positive regulation of stress fiber assembly	biological process	Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. [GOC:ai]
positive regulation of focal adhesion assembly	biological process	Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. [GOC:ai]
protein localization to plasma membrane	biological process	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah]
positive regulation of substrate adhesion-dependent cell spreading	biological process	Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. [GOC:TermGenie, GOC:yaf]
positive regulation of plasma membrane repair	biological process	Any process that activates or increases the frequency, rate or extent of plasma membrane repair. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583]

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