Galactokinase

A galactokinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51570]

EC 2.7.1.6;
Galactose kinase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-(1,3-benzoxazol-2-ylamino)-5-spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclopentane]one	Homo sapiens (human)	IC50	4.2129	1	0

This protein enables 4 target(s):

Target	Category	Definition
galactokinase activity	molecular function	Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H+. [EC:2.7.1.6, RHEA:13553]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
galactose binding	molecular function	Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides. [GOC:jl, ISBN:0198506732]

This protein is located in 4 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 6 target(s):

Target	Category	Definition
galactose metabolic process	biological process	The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. [ISBN:0198506732]
galactose catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose. [ISBN:0198506732]
galactitol metabolic process	biological process	The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. [ISBN:0198506732]
galactose catabolic process via UDP-galactose	biological process	The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose. [GOC:mah, MetaCyc:PWY-3821]
carbohydrate phosphorylation	biological process	The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. [ISBN:0198506732]
glycolytic process from galactose	biological process	The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP. [GOC:dph, ISBN:0201090910]