Carboxypeptidase N catalytic chain

A carboxypeptidase N catalytic chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15169]

Synonyms

CPN;
EC 3.4.17.3;
Anaphylatoxin inactivator;
Arginine carboxypeptidase;
Carboxypeptidase N polypeptide 1;
Carboxypeptidase N small subunit;
Kininase-1;
Lysine carboxypeptidase;
Plasma carboxypeptidase B;
Serum carboxyp

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sq 24798	Homo sapiens (human)	IC50	0.0020	1	1
sq 24798	Homo sapiens (human)	Ki	0.0020	1	1
anabaenopeptin b	Homo sapiens (human)	IC50	5.4000	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
metallocarboxypeptidase activity	molecular function	Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
bradykinin catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin. [GOC:BHF, GOC:rl]
protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah]
response to glucocorticoid	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:ai, PMID:9884123]
peptide metabolic process	biological process	The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. [GOC:go_curators]
protein processing	biological process	Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]

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