Page last updated: 2024-08-07 11:22:38

Carboxypeptidase N catalytic chain

A carboxypeptidase N catalytic chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15169]

Synonyms

CPN;
EC 3.4.17.3;
Anaphylatoxin inactivator;
Arginine carboxypeptidase;
Carboxypeptidase N polypeptide 1;
Carboxypeptidase N small subunit;
Kininase-1;
Lysine carboxypeptidase;
Plasma carboxypeptidase B;
Serum carboxyp

Research

Bioassay Publications (3)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Compounds (2)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
sq 24798Homo sapiens (human)IC500.002011
sq 24798Homo sapiens (human)Ki0.002011
anabaenopeptin bHomo sapiens (human)IC505.400011

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
metallocarboxypeptidase activitymolecular functionCatalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Involved In

This protein is involved in 5 target(s):

TargetCategoryDefinition
bradykinin catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of the peptide bradykinin. [GOC:BHF, GOC:rl]
protein catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:mah]
response to glucocorticoidbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:ai, PMID:9884123]
peptide metabolic processbiological processThe chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. [GOC:go_curators]
protein processingbiological processAny protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]