Xaa-Pro dipeptidase

An Xaa-Pro dipeptidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P12955]

X-Pro dipeptidase;
EC 3.4.13.9;
Imidodipeptidase;
Peptidase D;
Proline dipeptidase;
Prolidase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
jtp 4819	Homo sapiens (human)	IC50	100.0000	1	1
apstatin	Homo sapiens (human)	IC50	4.9000	1	1

This protein enables 6 target(s):

Target	Category	Definition
metallocarboxypeptidase activity	molecular function	Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
manganese ion binding	molecular function	Binding to a manganese ion (Mn). [GOC:ai]
metalloaminopeptidase activity	molecular function	Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]
proline dipeptidase activity	molecular function	Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal = L-proline + a standard alpha amino acid. [EC:3.4.13.9]
peptidase activity	molecular function	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]

This protein is located in 1 target(s):

Target	Category	Definition
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is involved in 4 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
amino acid metabolic process	biological process	The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. [ISBN:0198506732]
collagen catabolic process	biological process	The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194]
negative regulation of programmed cell death	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. [GOC:jl]