Porphobilinogen deaminase

A porphobilinogen deaminase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08397]

PBG-D;
EC 2.5.1.61;
Hydroxymethylbilane synthase;
HMBS;
Pre-uroporphyrinogen synthase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2,5-dimethylpyrrole	Homo sapiens (human)	Ki	3.0000	1	0

This protein enables 2 target(s):

Target	Category	Definition
hydroxymethylbilane synthase activity	molecular function	Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4. [EC:2.5.1.61, RHEA:13185]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 5 target(s):

Target	Category	Definition
protoporphyrinogen IX biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. [GOC:go_curators]
heme biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. [GOC:jl, PMID:11788607]
heme A biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3. [GOC:ai, PMID:11788607]
heme B biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of heme B, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes. [GOC:yaf, PMID:29414780]
heme O biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. [GOC:jid]