Potassium channel subfamily K member 5

A potassium channel subfamily K member 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95279]

Acid-sensitive potassium channel protein TASK-2;
TWIK-related acid-sensitive K(+) channel 2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
a 1899	Homo sapiens (human)	IC50	12.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
potassium channel activity	molecular function	Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
potassium ion leak channel activity	molecular function	Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. [GOC:mtg_transport, ISBN:0815340729]
outward rectifier potassium channel activity	molecular function	Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. [GOC:mah]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is part of 1 target(s):

Target	Category	Definition
monoatomic ion channel complex	cellular component	A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective monoatomic ion transport down its electrochemical gradient. [GOC:mah, ISBN:071673706X]

This protein is involved in 5 target(s):

Target	Category	Definition
potassium ion transport	biological process	The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
potassium ion export across plasma membrane	biological process	The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:11932440]
potassium ion import across plasma membrane	biological process	The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. [PMID:9139127]
stabilization of membrane potential	biological process	The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, ISBN:0198506732]
potassium ion transmembrane transport	biological process	A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]