A lathosterol oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75845]
EC 1.14.19.20;
C-5 sterol desaturase;
Delta(7)-sterol 5-desaturase;
Delta(7)-sterol C5(6)-desaturase;
Lathosterol 5-desaturase;
Sterol-C5-desaturase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| trifluoperazine hydrochloride | Homo sapiens (human) | INH | 1.0000 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| C-5 sterol desaturase activity | molecular function | Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. [MetaCyc:RXN3O-227] |
| iron ion binding | molecular function | Binding to an iron (Fe) ion. [GOC:ai] |
| delta7-sterol 5(6)-desaturase activity | molecular function | Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O. [RHEA:46556] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| lipid metabolic process | biological process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma] |
| cholesterol biosynthetic process via desmosterol | biological process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol. [GOC:mah, MetaCyc:PWY66-4] |
| cholesterol biosynthetic process via lathosterol | biological process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol. [GOC:mah, MetaCyc:PWY66-341] |