Page last updated: 2024-08-07 21:04:36
Aurora kinase B
An aurora kinase B that is encoded in the genome of mouse. [OMA:O70126, PRO:DNx]
Synonyms
EC 2.7.11.1;
Aurora 1;
Aurora- and IPL1-like midbody-associated protein 1;
Aurora/IPL1-related kinase 2;
ARK-2;
Aurora-related kinase 2;
STK-1;
Serine/threonine-protein kinase 12;
Serine/threonine-protein kinase 5;
Ser
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
Compounds (1)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| mln8054 | Mus musculus (house mouse) | IC50 | 0.1720 | 4 | 4 |
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.Journal of medicinal chemistry, , Sep-13, Volume: 55, Issue:17, 2012
Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase.Proceedings of the National Academy of Sciences of the United States of America, , Mar-06, Volume: 104, Issue:10, 2007